Figure 1.

A visual depiction of the process of conducting simulation studies used in this work to evaluate the Correlated Beta (CoBe) and other potential approaches of vaccine dose optimisation (red). These were tested by simulating clinical trials (purple) based on ‘scenarios’ (blue). Repeated simulation of clinical trials was conducted for different dose-optimisation approach/scenario pairs, and metrics related to how effectively optimal dose was located were calculated. These were tabulated and compared to assess these approaches. These analyses were used with considerations of several open topics in vaccine dose-optimisation (green).