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. 2022 Sep 19;107(12):3231–3241. doi: 10.1210/clinem/dgac535

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Attenuated GRP94 expression in nondiabetic elderly individuals influences beta cell identity. (A) Representative images of pancreatic section staining for GRP94 (red), insulin (green), and Dapi (blue) in young, middle-aged, and elderly groups. (B) Quantitative analysis of GRP94 intensity in young, middle-aged, and elderly groups; correlation of quantified GRP94 expression with age. (C) Immunoblot showed expression of GRP94 protein in ShGRP94 cells; band intensities normalized based on the corresponding TUBULIN intensity (n = 3). (D) Relative mRNA expression of transcription factors, genes involved in beta cell function, and progenitor cells in shGRP94 cells (n = 4). Scale bars, 20 μm. Data present means ± SD. The r of Pearson correlation and P values were shown in each panel. n = 7 in the young group, n = 4 in Middle-aged group, n = 6 in Elderly group. *P < .05, **P < .01, ***P < .001.