Table 1.
Patient Eligibility Criteria for Inclusion in the EnAKT LKD Trial Analysis.
| Criteria | Data sources | |
|---|---|---|
| 1 | Patients (aged 18-75 years) who were approaching the need for dialysis on November 1, 2017, or demonstrated they were approaching the need for dialysis between November 2, 2017, and September 30, 2021. “Approaching the need for dialysis” defined by evidence of a multi-care kidney clinic visit with (i) or (ii): (i) An eGFR <15 mL/min/1.73 m2 a (ii) A 2-year predicted risk of kidney failure (calculated using the kidney failure risk equation [KFRE])b≥ 25% To ensure stability of kidney function, at least 2 eGFR or 2 KFRE measures were required to enter the cohort, and these measures had to be separated by at least >90 days but within 365 days. or Patients (aged 18-75 years) who were receiving outpatient maintenance dialysis (in a dialysis center or at home) on November 1, 2017, or initiated maintenance dialysis between November 2, 2017, and September 30, 2021. |
Ontario Renal Reporting System, Ontario Laboratories Information System, Registered Persons Database |
| 2 | Patient has no evidence of any of the following recorded contraindications to receiving a kidney transplant:c End-stage kidney disease (ESKD) Charlson comorbidity index score ≥712, home oxygen use, dementia, living in a long-term care facility, received ≥1 physician house call in past year, or any history of the following cancers: bladder, cervical, colorectal, liver, lung, lymphoma, active multiple myeloma.13 Patients are not receiving conservative renal care; these patients have advanced CKD (ie, individuals with an eGFR <15 mL/min/1.73 m2 excluding individuals on dialysis) and have decided not to pursue dialysis or kidney transplantation. | Canadian Institute for Health Information Discharge Abstract Database and Same Day Surgery, Assistive Devices Program, Ontario Dementia Database, Continuing Care Reporting System, Ontario Health Insurance Plan, Ontario Cancer Registry, Ontario Renal Reporting System |
| 3 | Data cleaning steps (ie, invalid individual identifiers which would prevent linkage across databases, missing age or sex, death on or before index, etc.). We expect very few patients (<0.5%) will be excluded for these reasons. | Registered Persons Database |
Abbreviations: eGFR = estimated glomerular filtration rate; KFRE = kidney failure risk equation.
a
Using the 2021 Chronic Kidney Disease–Epidemiology Collaboration Equation, without race.14
b
Estimated using the Kidney Failure Risk Equation (https://kidneyfailurerisk.com).
c
These contraindications were defined based on analysis of 80+ characteristics in adult patients approaching the need for dialysis or receiving maintenance dialysis between 2013 and 2015; >97% of patients with ≥1 of these characteristics or with an age over 75 years did not receive a kidney transplant within a median follow-up of 3.2 years.13