Table 1.
Statistically significant metabolites in U87 cells treated with (A) paclitaxel 4.2 nM and (B) paclitaxel 4.2 nM + etoposide 10 μg/mL.
| A. Statistically Significant Metabolites in U87 Cell Line Treated with Paclitaxel 4.2 nM/mL | ||||
|---|---|---|---|---|
| Metabolite | t-stat | p-value | FDR | Fold change |
| ADP | 39.479 | 0.000025 | 0.00045982 | 0.0073262 |
| Guanosine | 19.744 | 0.00017013 | 0.0017391 | 0.01855 |
| Guanine | 27.592 | 0.000075 | 0.0011507 | 0.018726 |
| Hypoxanthine | 29.998 | 0.00000482 | 0.00017402 | 0.028151 |
| L-Methionine | 11.449 | 0.0010822 | 0.0066372 | 0.031249 |
| p-Hydroxyphenylacetic acid | 12.337 | 0.00090239 | 0.00593 | 0.031378 |
| Glycyl-L-leucine | 11.288 | 0.00087297 | 0.00593 | 0.046307 |
| Adenine | 15.341 | 0.0000249 | 0.00045982 | 0.066085 |
| Glycerophosphocholine | 28.954 | 0.000000113 | 0.0000104 | 0.067262 |
| Pyroglutamic acid | 6.3228 | 0.0066699 | 0.027892 | 0.075638 |
| Inosine | 13.845 | 0.0005007 | 0.00458 | 0.081824 |
| Niacinamide | 19.588 | 0.00000567 | 0.00017402 | 0.084552 |
| L-Phenylalanine | 14.813 | 0.00063069 | 0.0048353 | 0.08486 |
| Spermine | 7.2734 | 0.0022883 | 0.01108 | 0.11408 |
| Uric acid | 22.543 | 0.00014664 | 0.0017391 | 0.11878 |
| Thymidine | 6.5862 | 0.0071226 | 0.02849 | 0.13229 |
| L-Arginine | 13.13 | 0.00015563 | 0.0017391 | 0.1326 |
| Cytidine | 7.7175 | 0.0045226 | 0.019813 | 0.14374 |
| L-Tryptophan | 9.8826 | 0.0021262 | 0.010867 | 0.1597 |
| Guanosine 5’-diphosphate | 11.515 | 0.0014062 | 0.0080855 | 0.16321 |
| Cyclic AMP | 8.3747 | 0.00054761 | 0.00458 | 0.23873 |
| Androstenedione | 4.5213 | 0.010954 | 0.038761 | 0.66828 |
| Sphinganine | 4.9041 | 0.0088823 | 0.034049 | 0.68976 |
| L-Norleucine | 6.6297 | 0.0030279 | 0.013928 | 0.71434 |
| Mevalonic acid | −3.8293 | 0.010428 | 0.038375 | 1.1212 |
| Nutriacholic acid | −10.591 | 0.0017986 | 0.0097337 | 6.25 |
| B. Statistically significant metabolites in U87 cell line treated with paclitaxel 4.2 nM /mL + etoposide 10 μg/mL | ||||
| Metabolite | t-stat | p-value | FDR | Fold change |
| ADP | 39.641 | 0.0000273 | 0.00041814 | 0.0062162 |
| Guanosine | 20.192 | 0.00022842 | 0.0026268 | 0.010662 |
| Guanine | 27.875 | 0.0000928 | 0.0012194 | 0.016895 |
| Thymidine | 7.3937 | 0.0048716 | 0.021342 | 0.022396 |
| Hypoxanthine | 28.231 | 0.00000129 | 0.0000592 | 0.029428 |
| Glycerophosphocholine | 35.644 | 0.000000565 | 0.000052 | 0.061413 |
| Inosine | 13.625 | 0.00028557 | 0.0029192 | 0.069193 |
| Glycyl-L-leucine | 11.044 | 0.0009866 | 0.0069563 | 0.069508 |
| Uric acid | 21.477 | 0.0000139 | 0.00036381 | 0.075097 |
| Niacinamide | 20.815 | 0.000019 | 0.00036381 | 0.091824 |
| L-Phenylalanine | 14.45 | 0.00060549 | 0.0055705 | 0.10242 |
| Pyroglutamic acid | 6.1554 | 0.0081168 | 0.032467 | 0.10904 |
| Cyclic AMP | 10.615 | 0.0010586 | 0.0069563 | 0.13018 |
| Adenine | 13.059 | 0.0000198 | 0.00036381 | 0.13747 |
| Cytidine | 7.7175 | 0.0045226 | 0.020804 | 0.14374 |
| L-Methionine | 10.229 | 0.0018547 | 0.0089805 | 0.14382 |
| p-Hydroxyphenylacetic acid | 10.849 | 0.0016757 | 0.0089805 | 0.15864 |
| Guanosine 5’-diphosphate | 11.515 | 0.0014062 | 0.0086245 | 0.16321 |
| L-Tryptophan | 9.6991 | 0.0017879 | 0.0089805 | 0.16393 |
| Spermine | 5.7422 | 0.0016656 | 0.0089805 | 0.1902 |
| L-Arginine | 7.0817 | 0.00070717 | 0.0057029 | 0.23436 |
| L-Norleucine | 3.6225 | 0.0113 | 0.043318 | 0.80446 |
| 3,4-Dihydroxybenzeneacetic acid | 3.4628 | 0.013422 | 0.047493 | 0.93086 |
| Phosphocreatine | −3.5105 | 0.012692 | 0.046708 | 1.0684 |
| Mevalonic acid | −6.3456 | 0.00074386 | 0.0057029 | 1.1743 |
| Nutriacholic acid | −6.5371 | 0.0072758 | 0.030426 | 6.7728 |
FDR: false discovery rate.