Table 4.

Effect of Vaginal Microbiota on ART Outcome.

Parameter	Outcome * [Reference]	No Effect Author [Reference]	Positive Correlation Author [Reference]	Negative Correlation Author [Reference]	Comments
High richness of species		Wee et al. [39]		Campisciano et al. [41] Hyman et al. [54] Bernabeu et al. [55]
High diversity		Wee et al. [39] Amato et al. [57] Bernabeu et al. [55]		Campisciano et al. [41] Graspeuntner et al. [36] Hyman et al. [54] Haahr et al. [56] Amato et al. [57] Bernabeu et al. [55]	While alpha-diversity has unfavorable outcomes, betadiversity has no effect
High % of Lactobacillus sp. **	RIF [51]	Hyman et al. [54]	Graspeuntner et al. [36] (infectious) Kyono et al. [34] ($ or #) Bernabeu et al. [55] (p = 0.2) Koedooder et al. [60]	Kitaya et al. [51] #	Low load of lactobacilli associated with low pregnancy rate
L. crispatus (CST 1)	Live birth, miscarriage [63]	Haahr et al. [56]	Campisciano et al. [41] Graspeuntner et al. [36] Koedooder et al. [60] Riganelli et al. [50]	Koedooder et al. [60] Okwelogu et al. [63]	<60% has positive and >60% has negative correlation [60]
L. gasseri (CST 2)		Haahr et al. [56]	Okwelogu et al. [63] B. Lledo et al. [64]	Riganelli et al. [50] Campisciano et al. [41] Graspeuntner et al. [36]
L. iners (CST 3)	Live birth, miscarriage [63] PTB [64]	Graspeuntner et al. [36]	Riganelli et al. [50]	Wang et al. [58] Okwelogu et al. [63] B. Lledo et al. [64]
L. jensenii (CST 5)		Haahr et al. [56]		Koedooder et al. [60]
CST 4 (diverse bacteria) Presence of other species—No effect—Haahr et al. [56]
Bifidobacterium sp.		Amato et al. [57]		Amato et al. [57] Wang et al. [58]
Gardnerella sp.				Koedooder et al. [60] Campisciano et al. [41] Wee et al. [39] Graspeuntner et al. [36] Bernabeu et al. [55] (p = 0.11) Riganelli et al. [50]	IS-pro type 1 (IST1) is associated with low pregnancy rate
Staphyllococcus sp.				Campisciano et al. [41]
Streptococcus sp.		Bernabeu et al. [55]		Riganelli et al. [50]
Atopobium sp.				Campisciano et al. [41]
Sneathia sp.				Graspeuntner et al. [36]
Ureaplasma parvum		Bernabeu et al. [55]		Campisciano et al. [41] Wee et al. [39]
Burkholderia sp.		Kitaya et al. [51]
Prevotella sp.				Campisciano et al. [41] Graspeuntner et al. [36] Wang et al. [58]
Veillonella sp.				Campisciano et al. [41]
Closteridium		Bernabeu et al. [55]
Proteobacteria				Koedooder et al. [60]
Bacteroides	Live birth, miscarriage [63]			Okwelogu et al. [63]

sp. = Species, RIF = Recurrent implantation failure, PTB = Preterm birth, LBR = Live birth rate. * All studies included pregnancy rate/implantation rate/chemical pregnancy. Thus, any additional outcome is mentioned here. ** Cut-off ≥ 90% = #, cut-off value ≥ 80% = $.