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IND-2 inhibits TOPO2 activity and human kinetoplast DNA decatenation. Catenated kinetoplast DNA was incubated with human TOPO2α in presence of the indicated compounds at 37 °C for 30 min. DNA samples were separated by electrophoresis on a 1% agarose gel. The positions of the catenated DNA (F1), decatenated catenated products (FII), and linear DNA (NOCi-kDNA—Non-circular kinetoplast DNA; L-kDNA—Linearized kinetoplast DNA; RCi-kDNA—Relaxed circular kinetoplast DNA.
