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. 2022 Nov 17;12(11):1128. doi: 10.3390/metabo12111128

Figure 5.

Figure 5

Silencing of PKM2 could inhibit inflammation. (A) The expression of PKM2 was detected by WB; (B) cells transfected with siRNA for 24 h or 72 h (si-PKM2); (C) TGT-induced cells transfected with si-PKM2 72 h with or without GA; (D–F) the results were analyzed by WB. Data are expressed as the mean ± s; ## p < 0.01, ### p < 0.001 vs. control; * p < 0.05, ** p < 0.01, *** p < 0.001 vs. model or DMSO, n = 3; (G–I) the levels of TNF-α, IL-1β and IL-6 in si-PKM2-transfected cells treated with TGT or GA, n = 3; (J) localization of PKM2 (red) verified by immunofluorescence staining (40×).