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. 2022 Nov 13;26:100559. doi: 10.1016/j.bbih.2022.100559

Table 2.

Mean (SD) or percent of inflammatory, infection, and immune markers by dementia status, adjusted for sex and age, HRS 2016 VBS (N=5959).


With Dementia
CIND
Normal
Adjusted Mean 95% CI Adjusted Mean 95% CI Adjusted Mean 95% CI
Inflammation
Albumin 3.91* 3.90, 3.92 3.94* 3.93, 3.94 3.97 3.97, 3.97
CRP (log) 0.82* 0.82, 0.83 0.83* 0.83, 0.83 0.84 0.84, 0.84
Neutrophil Lymphocyte Ratio (NLR) 2.46* 2.42, 2.50 2.38* 2.37, 2.40 2.27 2.26, 2.27
Num of High-Risk z scored Cytokine Quartiles 1.55* 1.50, 1.60 1.43* 1.40, 1.45 1.26 1.25, 1.26
 IL6 Risk Quartile 0.30* 0.30, 0.31 0.28* 0.28, 0.29 0.25 0.25, 0.25
 IL10 Risk Quartile 0.30* 0.29, 0.31 0.28* 0.28, 0.28 0.25 0.25, 0.25
 IL-1Ra Risk Quartile 0.24* 0.24, 0.24 0.24* 0.24, 0.24 0.25 0.25, 0.25
 TGFβ1 Risk Quartile 0.33* 0.32, 0.34 0.30* 0.29, 0.30 0.25 0.25, 0.25
 TNFR1 Risk Quartile 0.38* 0.36, 0.40 0.33* 0.32, 0.33 0.25 0.25, 0.26
Immune Functioning
CMV Seronegative and Borderline 10.61%* 4.94, 16.29 23.11%* 19.67, 26.55 39.96% 38.17, 41.75
CMV Seropositive 1st Tertile 30.10%* 22.56, 37.65 26.11% 22.67, 29.55 20.07% 18.65, 21.49
CMV Seropositive 2nd Tertile 27.84% 20.77, 34.91 23.29% 19.97, 26.61 20.80% 19.34, 22.26
CMV Seropositive 3rd Tertile 31.44%* 23.73, 39.14 27.49%* 23.91, 31.06 19.17% 17.73, 20.61
CD4+ TN/TM 0.99 0.98, 1.00 0.98 0.98, 0.99 0.98 0.98, 0.98
CD8+ TN/TM 0.27* 0.26, 0.29 0.31* 0.30, 0.32 0.36 0.36, 0.37

*p < .05 indicates difference from normal dementia status.