Table 3.

Nested multinomial regressions of predicting dementia and cognitive impairment without dementia from individual inflammation and immune functioning biomarkers, HRS 2016 VBS (N = 5959).

	Model 1		Model 2
	Dementia	CIND	Dementia	CIND
	RRR	RRR	RRR	RRR
Inflammation
Albumin	0.38 [0.23, 0.61]***	0.69 [0.53, 0.91]**	0.55 [0.33, 0.92]*	0.86 [0.66, 1.14]
CRP (log)	1.11 [0.95, 1.29]	1.04 [0.96, 1.13]	1.05 [0.90, 1.22]	0.99 [0.91, 1.07]
Neutrophil Lymphocyte Ratio (NLR)	0.99[0.89, 1.12]	1.02 [0.96, 1.08]	1.08 [0.97, 1.20]	1.07 [1.00, 1.14]*
Number of High-Risk z scored Cytokine Quartiles	1.20 [1.04, 1.39]*	1.17 [1.09, 1.27]***	1.22 [1.06, 1.41]**	1.17 [1.08, 1.27]***
Immune Functioning
CMV Status (Seronegative and borderline as reference)
CMV 1st Tertile	3.37 [2.04, 5.57] ***	1.78 [1.42, 2.23] ***	1.87 [1.11, 3.15]*	1.22 [0.96, 1.54]
CMV 2nd Tertile	3.31 [1.98, 5.54] ***	1.65 [1.31, 2.08] ***	1.62 [0.94, 2.78]	1.09 [0.85, 1.39]
CMV 3rd Tertile	3.65 [2.19, 6.08] ***	2.04 [1.63, 2.56] ***	1.69 [0.99, 2.89]	1.26 [0.99, 1.61]
CD4+ TN/TM	0.72 [0.55, 0.94]*	0.81 [0.71, 0.92]**	0.96 [0.74, 1.26]	0.98 [0.86, 1.12]
CD8+ TN/TM	1.85 [1.21, 2.83]**	1.20 [0.93, 1.55]	1.12 [0.70, 1.80]	0.85 [0.64, 1.12]
Age	1.11 [1.09, 1.13]***	1.07 [1.06, 1.08]***	1.12 [1.10, 1.14]***	1.07 [1.06, 1.08]***
Female	0.93 [0.67, 1.28]	0.85 [0.72, 1.00]	0.82 [0.59, 1.14]	0.79 [0.67, 0.94]**
Race/ethnicity (NH White/other as Ref)
NH Black			7.26 [4.67, 11.29]***	3.88 [3.00, 5.01]***
Hispanic			5.05 [3.26, 7.85]***	2.71 [2.10, 3.50]***
Education (13–15 yrs as Ref)
0–12 yrs			3.03 [1.93, 4.77]***	2.01 [1.64, 2.47]***
16+ yrs			0.21 [0.08, 0.50]***	0.45 [0.34, 0.60]***
APOE4	1.38 [1.03, 1.86]*	1.36 [1.17, 1.58]***	1.41 [1.04, 1.93]*	1.35 [1.15, 1.58]***
Pseudo R2	0.1778		0.2862

***p < .001; **p < .01; *p < .05.