Table 5.
DTP NCI five-dose screening for compounds 1a, 3e, and curcumin.
| PANEL | CELL LINE 1 | 1a | 3e | Curcumin | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| GI50 | TGI | LC50 | GI50 | TGI | LC50 | GI50 | TGI | LC50 | ||
| Leukemia | CCRF-CEM | 5.65 | 4.7 | 4 | 5.4 | 4 | 4 | 5.52 | 4.81 | 4 |
| HL-60(TB) | 5.63 | 4.77 | 4 | 5.63 | 5.07 | 4 | 5.14 | 4.60 | 4.04 | |
| K-562 | 5.97 | 4 | 4 | 5.74 | 4 | 4 | 5.51 | 4.26 | 4 | |
| MOLT-4 | 5.69 | 4.72 | 4 | 5.49 | 4 | 4 | 5.33 | 4.75 | 4.12 | |
| RPMI-8226 | 6.41 | 5.63 | 4 | 5.58 | 4 | 4 | 5.68 | 5.20 | 4 | |
| Panel average | 5.87 | 4.76 | 4 | 5.57 | 4.21 | 4 | 5.43 | 4.72 | 4.03 | |
| Non-Small-Cell Lung Cancer | A549/ATCC | 4 | 4 | 4 | 5.32 | 4 | 4 | 4.89 | 4.50 | 4.11 |
| EKVX | 5.3 | 4 | 4 | 5.21 | 4 | 4 | 4.82 | 4.45 | 4.10 | |
| HOP-62 | 5.17 | 4 | 4 | 5.28 | 4 | 4 | 5.44 | 4.72 | 4.24 | |
| HOP-92 | 4.82 | 4.08 | 4 | 5.6 | 4.63 | 4 | NT | NT | NT | |
| NCI-H226 | 5.63 | NT 1 | 4 | 4.83 | 4 | 4 | 4.73 | 4.27 | 4 | |
| NCI-H23 | 5.52 | 4 | 4 | 5.36 | 4 | 4 | 5.25 | 4.50 | 4 | |
| NCI-H322M | 5.17 | 4 | 4 | 4.84 | 4 | 4 | 4.78 | 4.49 | 4.21 | |
| NCI-H460 | 5.51 | 4.95 | 4 | 5.37 | 4 | 4 | 5.09 | 4.64 | 4.22 | |
| NCI-H522 | 5.43 | 4.72 | 4 | 5.72 | 5.17 | 4.02 | 5.27 | 4.78 | 4.07 | |
| Panel average | 5.17 | 4.22 | 4.00 | 5.28 | 4.20 | 4 | 5.03 | 4.54 | 4.12 | |
| Colon Cancer | COLO-205 | 5.72 | 5.31 | 4.4 | 5.08 | 4.01 | 4 | 4.87 | 4.54 | 4.21 |
| HCC-2998 | 5.77 | 5.49 | 5.22 | 4.71 | 4 | 4 | 5.52 | 5.09 | 4.53 | |
| HCT-116 | 6.5 | 5.88 | 5.39 | 5.59 | 4.75 | 4 | 5.53 | 5.03 | 4.28 | |
| HCT-15 | 6.11 | 5.21 | 4.25 | 5.56 | 4 | 4 | 5.39 | 4.73 | 4.14 | |
| HT-29 | 6.12 | 5.58 | 5.09 | 5.58 | 4.97 | 4 | 5.29 | 4.49 | 4 | |
| KM12 | 5.8 | 5.43 | 5.07 | 5.16 | 4 | 4 | 5.27 | 4.71 | 4.19 | |
| SW-620 | 5.97 | 5.48 | 4.97 | 5.48 | 4 | 4 | 5.38 | 4.67 | 4.07 | |
| Panel average | 6.00 | 5.48 | 4.91 | 5.31 | 4.25 | 4 | 5.32 | 4.75 | 4.20 | |
| CNS Cancer | SF-268 | 5.6 | 5.07 | 4 | 5.11 | 4 | 4 | 5.15 | 4.44 | 4 |
| SF-295 | 5.52 | 4.51 | 4 | 5.53 | 4.75 | 4 | 5.10 | 4.68 | 4.32 | |
| SF-539 | 5.67 | 5.29 | 4.22 | 5.57 | 5.03 | 4.09 | 5.55 | 5.05 | 4.48 | |
| SNB-19 | 5.51 | 4.63 | 4 | 5.39 | 4.04 | 4 | 5.05 | 4.61 | 4.20 | |
| SNB-75 | 5.6 | 4.47 | 4 | 5.38 | 4.34 | 4 | 5.17 | 4.74 | 4.35 | |
| U251 | 5.81 | 5.44 | 5.07 | 5.42 | 4.73 | 4 | 5.33 | 4.78 | 4.31 | |
| Panel average | 5.62 | 4.90 | 4.22 | 5.40 | 4.48 | 4.02 | 5.22 | 4.72 | 4.28 | |
| Melanoma | LOX IMVI | 5.84 | 5.49 | 5.15 | 5.51 | 4.54 | 4 | 5.57 | 5.07 | 4 |
| MALME-3M | 5.24 | 4.1 | 4 | 5.21 | 4 | 4 | 4.85 | 4.56 | 4.27 | |
| M14 | 5.77 | 5.36 | 4.24 | 5.51 | 4.58 | 4 | 5.42 | 4.80 | 4.35 | |
| MDA-MB-435 | 5.94 | 5.53 | 5.11 | 6.03 | 5.41 | 4.19 | 5.53 | 4.92 | 4.40 | |
| SK-MEL-2 | 4.51 | 4 | 4 | 5.54 | 4.73 | 4 | 4.78 | 4.39 | 4.06 | |
| SK-MEL-28 | 5.74 | 5.4 | NT | 5.3 | 4 | 4 | 5.35 | 4.80 | 4.30 | |
| SK-MEL-5 | 5.67 | 5.21 | 4 | 5.66 | 4.99 | 4 | 5.06 | 4.65 | 4.28 | |
| UACC-257 | 5.61 | 5.13 | 4 | 4.97 | 4 | 4 | 4.94 | 4.62 | 4.31 | |
| UACC-62 | 5.72 | 5.31 | 4.52 | 5.62 | 5 | 4 | 5.19 | 4.69 | 4.26 | |
| Panel average | 5.56 | 5.06 | 4.38 | 5.48 | 4.58 | 4.02 | 5.19 | 4.72 | 4.25 | |
| Ovarian Cancer | IGROV-1 | 5.57 | NT | 4 | 5.37 | 4 | 4 | 5.10 | 4.57 | 4.09 |
| OVCAR-3 | 5.55 | 5 | 4 | 5.3 | 4.09 | 4 | 5.18 | 4.61 | 4.17 | |
| OVCAR-4 | 5.39 | 4 | 4 | 5.04 | 4 | 4 | 5.03 | 4.44 | 4 | |
| OVCAR-5 | 5.6 | 5.09 | 4 | 5.31 | 4.27 | 4 | 4.78 | 4.45 | 4.12 | |
| OVCAR-8 | 5.53 | 4 | 4 | 5.06 | 4 | 4 | 5.13 | 4.55 | 4.08 | |
| NCI/ADR-RES | 5.38 | 4 | 4 | 5.45 | 4 | 4 | 5.14 | 4.12 | 4 | |
| SK-OV-3 | 4.44 | 4 | 4 | 5.06 | 4.03 | 4 | 5.05 | 4.68 | 4.33 | |
| Panel average | 5.35 | 4.35 | 4.00 | 5.23 | 4.06 | 4 | 5.06 | 4.49 | 4.11 | |
| Renal Cancer | 786-0 | 5.64 | 5.1 | 4 | 5.25 | 4 | 4 | 5.48 | 4.97 | 4.42 |
| A-498 | 5.65 | 4.7 | 4 | 6.62 | 5.04 | 4 | 4.80 | 4.48 | 4.16 | |
| ACHN | 5.69 | 5.27 | 4 | 4.86 | 4 | 4 | 4.91 | 4.54 | 4.17 | |
| CAKI-1 | 5.5 | 4 | 4 | 4.94 | 4 | 4 | 4.92 | 4.60 | 4.30 | |
| RXF-393 | 5.83 | 5.52 | 5.2 | 5.1 | 4.11 | 4 | 5.52 | 4.95 | 4.27 | |
| SN12C | 5.51 | 4.75 | 4 | 5.26 | 4 | 4 | 5.08 | 4.60 | 4.20 | |
| TK-10 | 5.42 | 4.6 | 4 | 5.42 | 4.56 | 4 | 4.85 | 4.51 | 4.18 | |
| UO-31 | 5.79 | 5.47 | 5.14 | 5.32 | 4 | 4 | 4.95 | 4.61 | 4.27 | |
| Panel average | 5.63 | 4.93 | 4.29 | 5.35 | 4.21 | 4 | 5.06 | 4.66 | 4.25 | |
| Prostate Cancer | PC-3 | 5.48 | 4 | 4 | 5.39 | 4 | 4 | 5.06 | 4.59 | 4.15 |
| DU-145 | 5.51 | 4.85 | 4 | 4.82 | 4 | 4 | 4.81 | 4.53 | 4.25 | |
| Panel average | 5.50 | 4.43 | 4.00 | 5.11 | 4.00 | 4 | 4.93 | 4.56 | 4.20 | |
| Breast Cancer | MCF7 | 6.29 | 5.02 | 4 | 5.46 | 4 | 4 | 5.48 | 4.46 | 4 |
| MDA-MB-231/ATCC | 5.65 | 5.22 | 4 | 5.44 | 4.36 | 4 | 4.75 | 4.25 | 4 | |
| HS 578T | 5.57 | 4 | 4 | 5.43 | 4.32 | 4 | 4.96 | 4.23 | 4 | |
| BT-549 | 5.74 | 5.35 | 4.66 | 5.54 | 4.45 | 4 | 5.30 | 4.86 | 4.37 | |
| T-47D | 5.65 | 4 | 4 | 5.46 | 4.09 | 4 | 5.08 | 4.33 | 4 | |
| MDA-MB-468 | 5.81 | 5.43 | 4 | 5.54 | 4.56 | 4 | NT | NT | NT | |
| Panel average | 5.79 | 4.84 | 4.11 | 5.48 | 4.30 | 4 | 5.11 | 4.43 | 4.07 | |
| Overall average | 5.59 | 4.81 | 4.24 | 5.37 | 4.28 | 4.01 | 5.16 | 4.63 | 4.17 | |
| Range | 4–6.5 | 4–5.88 | 4–5.39 | 4.71–6.62 | 4–5.41 | 4–4.19 | 4.73–5.68 | 4–5.20 | 4–4.53 | |
1 NT = not tested against the cell line.