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. 2022 Oct 31;14(11):2346. doi: 10.3390/pharmaceutics14112346

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Design and responsive mechanism of hypoxia-triggered srNPs. (A) Preparation and in vivo selectively hypoxia-activated mechanism of IDMs nanomedicines for eradicating advanced breast cancer. Reproduced with permission [99]. Copyright 2021, Elsevier. (B) Chemical structure and hypoxia-responsive mechanism of NI-based nanoparticles. Reproduced with permission [98]. Copyright 2018, Royal Society of Chemistry. (C) Schematic illustration of synthesized polymers and their mechanism of hypoxia-responsive disintegration in the TME. Reproduced with permission [100]. Copyright 2014, Wiley-VCH GmbH.