ADA	Anti-drug antibodies
ALK	Anaplastic lymphoma kinase
APC	Antigen-presenting cell
ATG	Antithymocyte globulin
BCG	Bacille Calmette–Guerin
CD	Cluster of differentiation
CRC	Colorectal cancer
DCs	Dendritic cells
DLBCL	Diffuse large B-cell lymphoma
dMMR	Deficient mismatch repair
DLs	Dose levels
EGFR	Epidermal growth-factor receptor
EMT	Epithelial-to-mesenchymal transition
ERK	Extracellular signal-regulated kinase
ER	Estrogen receptor
FDA	Food and Drug Administration
FGFR	Fibroblast growth-factor receptor
FOX	Forkhead box protein
GIST	Gastrointestinal stromal tumors
GCB	Germinal center B cell
GSK	GlaxoSmithKline
GLI	Glioma-associated oncogene homolog
Hh	Hedgehog
HNSCC	Head and neck squamous-cell carcinoma
HL	Hodgkin’s lymphoma
ICIs	Immune-checkpoint inhibitors
IFN	Interferon gamma
IL	Interleukin
IRF	Interferon regulatory factor
JAK	Janus kinase
Kras	Kirsten rat sarcoma viral oncogene
LAG	Lymphocyte-activation gene
MRI	Magnetic resonance imaging
MTD	Maximum tolerated dose
MCF	Michigan Cancer Foundation-7
MHC	Major histocompatibility complex
MET	Microenvironment
MSI-H	Microsatellite instability—high
MAPK	Mitogen-activated protein kinase
NSCLC	Non-small-cell lung cancer
NOTCH	Neurogenic locus notch homolog protein 1
TNF	Tumour necrosis factor
NFAT	Nuclear factor of activated T cells
OS	Overall survival
PDAC	Pancreatic ductal adenocarcinoma
PBMC	Peripheral blood mononuclear cells
PTEN	Phosphatase and tensin homolog
PKC	Protein kinase C
PET	Positron emission tomography
PD	Programmed cell death
PD-L	Programmed cell-death ligand
RAS	Rat sarcoma
RCC	Renal-cell carcinoma
STAT	Signal transducer and activator of transcription
SMO	Smoothened
TCR	T-cell receptor
TIM-3	T-cell immunoglobulin and mucin-domain-containing-3
TLR	Toll-like receptor
TNBC	Triple-negative breast cancer
TILs	Tumour-infiltrating lymphocytes
WNT	Wingless-related integration site