Extended Data Table 1. X-ray crystallography data collection and refinement statistics.

Metrics from X-ray crystal structure data collection and processing are indicated, including Fourier shell correlation (FSC). *Values in parentheses are for the highest-resolution shell.

	APO-SHOC2 (PDB ID: 7T7A)
Data collection
Space group	C 121
Cell dimensions
a, b, c (Å)	91.93, 103.03, 121.09
α, β, γ (°)	90.00, 101.92, 90.00
Resolution (Å)	48.5-1.79(1.85-1.79)*
Rsym or Rmerge	0.091(0.46)
I / σI	11.73(1.3)
Completeness (%)	96.82(94.26)
Redundancy	4.4 (4.5)
Refinement
Resolution (Å)	48.5*1.79
No. reflections	99833(9677)
Rwork / Rfree	0.20(0.30)/0.22(0.32)
No. atoms
Protein	7748
Ligand/ion	5
Water	550
B-factors	40.57
Protein	40.41
Ligand/ion	56.69
Water	42.70
R.m.s. deviations
Bond lengths (Å)	0.008
Bond angles (°)	1.01