Figure 3.

Naturally occurring N-abridged Aβ fragments activate FPR1 tenfold better than Aβ_1-42.A, comparison of mean Ca²⁺ peak responses of human (red) or mouse (blue) FPRs to a stimulation with 10 μM Aβ_1-40 and Aβ_1-42 or 5 μM of the natural occurring N-abridged variants Aβ_11-40 and Aβ_17-40 or with 10 μM of the C-abridged variants Aβ_1-10 and Aβ_1-16. Colored bars indicate responses of human (red) or mouse (blue) FPRs, n = 3, N = 1. B, concentration response curves of selected variants, n = 3, N = 1. C, left: scheme indicating the size and location of the different Aβ variants. Right: Table depicting the proposed 3D-structures and thresholds for minimal detectable activation during Ca²⁺ imaging of the responding Aβ variants. All Error bars, S.D. One-way ANOVA test, Dunnett post hoc test; ∗∗p ≤ 0.01; ∗∗∗p ≤ 0.001; ns, no significance. Aβ, amyloid beta; FPR, Formyl peptide receptor.