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. 2022 Nov 24;22:1211. doi: 10.1186/s12885-022-10293-0

Table 2.

Experimental validation of drug treatment predictions by CancerOmicsNet. GRmax values obtained for three cell lines treated with six drugs at various concentrations. For each treatment, two values collected from experiment A / experiment B are reported

Drug concentration Panc 04.03 DU 145 HCC70
JNJ-7706621 PP1 AZD6482 XMD8–92 GW2580 PI-103
1 nm −1.000 / -0.596 −1.000 / -0.771 − 0.344 / -0.147 − 0.791 / -0.998 − 0.086 / -0.361 0.176 / -0.077
3.162 nm −1.000 / -0.807 − 1.000 / -0.830 − 0.908 / -0.968 − 0.892 / -0.992 0.129 / -0.040 0.042 / 0.036
10 nm − 1.000 / -0.922 − 1.000 / -0.697 − 0.788 / -0.429 − 0.929 / -0.998 0.245 / 0.022 − 0.472 / -0.265
31.62 nm −1.000 / -0.708 − 1.000 / -0.257 − 0.609 / -0.995 − 0.962 / -0.996 − 0.131 / -0.048 − 0.274 / 0.176
100 nm − 1.000 / -0.818 − 0.999 / -0.908 − 0.977 / -0.991 − 0.840 / -0.999 − 0.421 / 0.335 0.158 / -0.076
316.2 nm −0.111 / -0.968 − 1.000 / -0.759 − 0.340 / -0.977 − 0.557 / -0.976 −0.116 / 0.556 − 0.353 / -0.437
1 μm − 0.570 / -0.982 −1.000 / -0.838 −0.581 / -0.982 − 0.892 / -0.996 0.139 / 0.249 0.238 / -0.330
3.162 μm −0.026 / -0.665 −1.000 / -0.738 −0.211 / -0.998 − 0.799 / -0.993 −0.206 / -0.345 − 0.943 / -0.884
10 μm − 0.188 / -0.723 −1.000 / -0.739 −0.987 / -0.995 − 0.714 / -0.852 −0.808 / -0.319 − 0.985 / -0.797