Table 2.
Anti-inflammatory activity (µmol/ml) of synthesized (E)-2-(3-(substitutedstyryl)-5-(substitutedphenyl)-4,5-dihydropyrazol-1-yl)benzo[d]thiazole derivatives (VI)
| Comp | Conc | %Inhibition ± SEM | IC50 | Comp | Conc | %Inhibition ± SEM | IC50 |
|---|---|---|---|---|---|---|---|
| Z1 |
500 250 125 62.5 31.25 |
46.38 ± 0.19** 42.52 ± 0.06** 38.07 ± 0.43** 33.51 ± 0.25** 31.69 ± 0.11** |
0.54 | Z11 |
500 250 125 62.5 31.25 |
31.00 ± 0.00** 28.72 ± 0.11** 26.26 ± 0.06** 21.92 ± 0.02** 18.47 ± 0.07** |
0.16 |
| Z2 |
500 250 125 62.5 31.25 |
70.42 ± 0.07 ns 58.88 ± 0.07** 40.54 ± 3.07** 33.39 ± 0.01** 27.21 ± 0.07** |
0.41 | Z12 |
500 250 125 62.5 31.25 |
82.53 ± 0.28** 75.28 ± 0.06** 62.96 ± 0.01** 54.98 ± 0.29** 43.97 ± 0.38** |
0.23 |
| Z3 |
500 250 125 62.5 31.25 |
71.11 ± 0.03 ns 65.23 ± 0.05** 57.86 ± 0.05** 46.90 ± 0.02** 34.71 ± 0.00** |
0.05 | Z13 |
500 250 125 62.5 31.25 |
79.26 ± 0.13** 77.17 ± 0.03** 73.51 ± 0.04** 63.28 ± 0.04** 42.12 ± 0.00** |
0.03 |
| Z4 |
500 250 125 62.5 31.25 |
42.26 ± 0.00** 38.37 ± 0.00** 35.91 ± 0.02** 29.49 ± 0.00** 25.14 ± 0.00** |
0.13 | Z14 |
500 250 125 62.5 31.25 |
29.58 ± 0.17** 26.98 ± 0.29** 24.54 ± 0.33** 20.04 ± 0.10** 16.73 ± 0.09** |
0.17 |
| Z5 |
500 250 125 62.5 31.25 |
44.16 ± 0.07** 41.06 ± 0.01** 36.32 ± 0.07** 32.92 ± 0.01** 29.15 ± 0.02** |
0.27 | Z15 |
500 250 125 62.5 31.25 |
39.57 ± 0.33** 36.83 ± 0.00** 34.62 ± 0.00** 29.58 ± 0.00** 26.53 ± 0.01** |
0.19 |
| Z6 |
500 250 125 62.5 31.25 |
77.70 ± 0.32** 62.26 ± 0.09** 42.24 ± 0.19** 28.67 ± 0.07** 22.17 ± 0.34** |
0.42 | Z16 |
500 250 125 62.5 31.25 |
57.24 ± 0.07** 45.39 ± 0.14** 37.15 ± 0.10** 28.20 ± 0.15** 24.08 ± 0.05** |
1.20 |
| Z7 |
500 250 125 62.5 31.25 |
50.23 ± 0.09** 42.92 ± 0.02** 37.68 ± 0.25** 26.65 ± 0.13** 22.15 ± 0.03** |
0.28 | Z17 |
500 250 125 62.5 31.25 |
71.05 ± 0.03 ns 60.72 ± 0.14** 51.87 ± 0.27** 43.38 ± 0.01** 38.31 ± 0.35** |
0.61 |
| Z8 |
500 250 125 62.5 31.25 |
48.57 ± 1.34** 35.98 ± 0.06** 27.95 ± 0.02** 20.48 ± 1.33** 17.30 ± 0.79** |
3.08 | Z18 |
500 250 125 62.5 31.25 |
51.07 ± 0.00** 46.05 ± 0.05** 37.66 ± 0.01** 35.63 ± 0.01** 31.12 ± 0.01** |
0.43 |
| Z9 |
500 250 125 62.5 31.25 |
86.05 ± 0.02** 64.45 ± 0.02** 49.63 ± 0.09** 33.12 ± 0.03** 26.53 ± 0.04** |
0.90 | Z19 |
500 250 125 62.5 31.25 |
58.11 ± 0.02** 54.56 ± 0.11** 48.08 ± 0.05** 36.74 ± 0.31** 26.95 ± 0.63** |
0.14 |
| Z10 |
500 250 125 62.5 31.25 |
80.14 ± 0.02** 55.13 ± 0.05** 38.64 ± 0.03** 28.13 ± 0.05** 24.72 ± 0.08** |
1.30 | Z20 |
500 250 125 62.5 31.25 |
32.22 ± 0.02** 30.19 ± 0.04** 27.25 ± 0.00** 24.24 ± 0.02** 21.28 ± 0.01** |
0.15 |
| STD |
500 250 125 62.5 31.25 |
70.53 ± 0.03 69.11 ± 0.01 66.53 ± 0.03 60.46 ± 0.03 50.55 ± 0.14 |
0.11 | ||||
This data is represented as Mean ± SEM, n = 3, values are significantly different as compared to positive control (STD) Ibuprofen (500 µg/ml) (**P < 0.01); ns- non-significant