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Classical and non-classical human DHFR inhibitors. The 2D chemical structures of methotrexate (ZINC01529323), edatrexate (ZINC01618702), pralatrexate (ZINC01536109), trimetrexate (ZINC00598852), piritrexim (ZINC00000640), and methylbenzoprim (ZINC03777839) were prepared with MarvinSketch v17.14, 2017, ChemAxon.
