Table 3.

Mathematical modelling of IBU release from effervescent matrix tablets in pH 1.2 HCl buffer (0.1 N).

Modelling	Formulation	Parameters				R2 Adjusted	AIC	MSC
Zero-order	IPM	k0 = 4.3977				0.9685	0.0607	2.6787
	5E	k0 = 2.2858				0.9566	−3.8335	2.5255
	10E	k0 = 1.6920				0.9624	−11.1238	2.5833
First-order	IPM	k1 = 0.0452				0.9714	−0.5353	2.7781
	5E	k1 = 0.0232				0.9544	−3.5304	2.4749
	10E	k1 = 0.0171				0.9640	−11.4244	2.6334
Higuchi’s	IPM	kH = 4.4344				0.9245	5.2908	1.8070
	5E	kH = 2.2293				0.7662	6.3148	0.8341
	10E	kH = 1.7110				0.9373	−7.2374	1.9356
Kosmeyer–Peppas	IPM	kKP = 4.4822		n = 0.8128		0.9860	−5.1810	3.5523
	5E	kKP = 2.1939		n = 1.2903		0.9736	−6.1534	2.9121
	10E	kKP = 1.7299		n = 0.7760		0.9892	−20.2020	4.0963
Hixson-Crowell	IPM	kHC = 0.0149				0.9705	−0.3396	2.7454
	5E	kHC = 0.0077				0.9551	−3.6304	2.4916
	10E	kHC = 0.0057				0.9635	−11.3240	2.6167
Hopfenberg	IPM	kHB = 0.0023		n = 93.2625		0.9642	1.4792	2.4423
	5E	kHB = 0.4191		n = 0.0390		0.9855	−9.8755	3.5325
	10E	kHB = 0.0014		n = 20.3999		0.9548	−9.4031	2.2965
Peppas–Sahlin	IPM	k1 = 2.7052	k2 = 1.7390		m = 0.5990	0.9862	−5.4580	3.5985
	5E	k1 = 1.2791	k2 = 0.8772		m = 0.9303	0.9752	−6.3063	2.9376
	10E	k1 = 1.1047	k2 = 0.6117		m = 0.5863	0.9891	−20.2437	4.1033

Remark: The significance of bold indicates the estimated parameters from the best-fitted mathematic model.