Skip to main content
. 2022 Nov 15;99(20):e2264–e2274. doi: 10.1212/WNL.0000000000201120

Figure 1. Burdens of Age-Related Neuropathologies.

Figure 1

The figure illustrates the burdens of neuropathologies in the human donors. Each column represents person-specific combination of pathologies present in the brain of individual donor case. The colors of the columns differentiate the clinical diagnosis proximate to death, that is, light blue columns are cases of no cognitive impairment, blue columns are cases of mild cognitive impairment, and dark blue columns are cases of dementia. The rows from bottom to top represent the presence of AD, neocortical Lewy bodies, TDP43 pathology beyond the amygdala, hippocampal sclerosis, macroscopic infarcts, microinfarcts, moderate-to-severe amyloid angiopathy, moderate-to-severe atherosclerosis, and moderate-to-severe arteriolosclerosis. AD = Alzheimer disease; LATE = limbic predominant age-related TDP-43 encephalopathy.