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Effects of knockdown GRP94 on the expression of IGF-1, IGF-1R, IGFBP-1, and IGFBP-3 in the cell supernatant of immortalized porcine HSCs. (A–D): The levels of IGF-1, IGF-1R, IGFBP-1 and IGFBP-3 in the cell supernatant of immortalized HSCs. Data were assessed with two-way ANOVA (main effects: ERS, shRNA, and their interaction), followed by Bonferroni’s multiple comparison post hoc test; the same letters mean no significant difference (p < 0.05) between groups.
