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. 2022 Nov 18;14(22):5014. doi: 10.3390/polym14225014

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Distribution and structures (repeating disaccharide units) of GAGs in the extracellular matrix. CS/DS, HS, and KS are linked to core proteins, whereas HA is free. “” and “” indicate that the hydroxyl can be substituted by a sulfate group and acetyl, respectively. It is worth noting that the structural formula represents the maximum degree of sulfation for each GAG type. “” only represents the possibility of being substituted by a sulfate group. Such as CS, they can be classified as CS-A (GlcA-GalNAc4S), CS-C (GlcA-GalNAc6S), CS-D (GlcA2S-GalNAc6S), CS-E (GlcA4S-GalNAc6S), etc. (Used with permission of Royal Society of Chemistry from ref. [1]; permission conveyed through Copyright Clearance Center, Inc).

Inline graphic — Distribution and structures (repeating disaccharide units) of GAGs in the extracellular matrix. CS/DS, HS, and KS are linked to core proteins, whereas HA is free. “” and “” indicate that the hydroxyl can be substituted by a sulfate group and acetyl, respectively. It is worth noting that the structural formula represents the maximum degree of sulfation for each GAG type. “” only represents the possibility of being substituted by a sulfate group. Such as CS, they can be classified as CS-A (GlcA-GalNAc4S), CS-C (GlcA-GalNAc6S), CS-D (GlcA2S-GalNAc6S), CS-E (GlcA4S-GalNAc6S), etc. (Used with permission of Royal Society of Chemistry from ref. [1]; permission conveyed through Copyright Clearance Center, Inc).