Table 1.
Results of cytoprotection assay of synthesized 4-substituted sulfonamidobenzoic acid derivatives against CVB3 Nancy.
| Compound ID | CC50, (μM) * | EC50, (μM) ** | SI |
|---|---|---|---|
| 2a | >710.20 | <8.76 | >81.1 |
| 2b | 39.96 ± 4.12 | >443.98 | <1 |
| 2c | 472.21 ± 38.17 | >474.57 | <1 |
| 2d | 624.66 ± 57.47 | 743.64 ± 67.32 | <1 |
| 2e | 437.17 ± 35.12 | >437.17 | <1 |
| 2f | 181.42 ± 19.21 | >688.93 | <1 |
| 2g | >228.31 | 12.33 ± 2.07 | >18.5 |
| 2h | >725.58 | >725.58 | >1 |
| 2i | 283.21 ± 31.09 | <28.58 | >10 |
| 3 | >640.35 | >426.90 | >1 |
| 4 | >227.27 | 13.21 ± 1.49 | >17.2 |
| 7a | 344.58 ± 32.16 | <9.88 | >34.8 |
| 7b | 473.67 ± 38.52 | <8.67 | >54.6 |
| 7c | >684.21 | <8.44 | >81.1 |
| 7d | 681.08 ± 54.82 | <8.39 | >81.1 |
| 7e | 531.24 ± 48.36 | >634.95 | <1 |
* CC50 is the cytotoxic concentration resulting in the death of 50% of the cells; CC50 was evaluated after 72 h of incubation of Vero cells with the compound only. ** EC50 is the 50% cytoprotective concentration leading to 50% cytoprotection after infection of cells with CVB3 at m.o.i 0.001; c SI is the selectivity index, the ratio of CC50/IC50. Compound 2a was used as a reference (positive control). The data presented were obtained from three independent experiments and the values for CC50 and EC50 are mean ± SD.