Table 2.
Virus-inhibiting properties of selected compounds against Coxsackievirus B3 (Nancy) in vitro.
| Compound | CC50, (μM) * | IC50, (μM) ** | SI |
|---|---|---|---|
| 2a | >1183.68 | 5.54 ± 0.89 | >213 |
| 2i | 1261.59 ± 110.34 | 37.85 ± 1.08 | 33 |
| 4 | >1135.25 | 4.29 ± 1.79 | >264 |
| 7a | >1335.58 | 4.22 ± 0.35 | >316 |
| 7b | 933.29 ± 75.13 | 11.14 ± 0.16 | 33 |
| 7c | >1140.36 | 19.55 ± 0.52 | >58 |
| 7d | >1135.13 | 19.61 ± 0.49 | >58 |
MOI = 0.01. * CC50 is the cytotoxic concentration resulting in the death of 50% of the cells; CC50 was evaluated after 24 h of incubation of Vero cells with the compound only. ** IC50 is the 50% virus-inhibiting concentration leading to 50% inhibition of virus replication after infection of cells with CVB3 at m.o.i 0.01; c SI is the selectivity index, the ratio of CC50/IC50. The data presented were obtained from three independent experiments and the values for CC50 and IC50 are mean ± SD of the experiment.