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HER2 protein score of canine mammary tumors. (A) Negative (0), showing no immuno-reactivity for HER2; (B) negative (1+), characterized by a weak incomplete membrane expression of HER2; (C) equivocal (2+), showing a complete or basolateral moderate HER2 expression; (D) overexpression (3+), characterized by an intense complete membranous labeling; (E) histogram representation of the number of cases showing the 4 scores of the IHC of HER2.
