Table 1.
Characteristics of 561 participants by AT group
| AT_group | A-T- (n = 316) |
A-T+ (n = 63) |
A+T+ (n = 182) |
p1 | p2 | p3 |
|---|---|---|---|---|---|---|
| Age, year | 72.0 ± 7.2 | 75.8 ± 7.6 | 75.6 ± 7.8 | <0.001a, b | ||
| Female | 177 (56.0) | 26 (41.3) | 93 (51.1) | 0.087 | ||
| Education, year | 16.6 ± 2.5 | 17.1 ± 2.5 | 16.1 ± 2.5 | 0.011c | ||
| Diagnosis | <0.001 | |||||
| NL | 230 (72.8) | 35 (55.6) | 50 (27.5) | |||
| CI | 86 (27.2) | 28 (44.4) | 132 (72.5) | |||
| APOEε4_carrierd | 63 (22.8) | 9 (17.0) | 88 (64.2) | <0.001b, c | ||
| Diabetes | 41 (13.0) | 10 (14.5) | 22 (12.1) | 0.743 | ||
| Hypertension | 123 (38.9) | 32 (50.8) | 85 (46.7) | 0.095 | ||
| Hyperlipidemia | 77 (24.4) | 27 (42.9) | 47 (25.8) | 0.010a, c | ||
| Cholesterole,mg/dl | 193.5 ± 30.8 | 204.1 ± 36.3 | 191.6 ± 48.2 | 0.411 | ||
| MMSE | 28.9 ± 1.3 | 28.6 ± 1.9 | 26.0 ± 4.0 | <0.001b, c | <0.001b, c | |
| GDS | 1.1 ± 1.5 | 1.6 ± 2.0 | 1.7 ± 1.8 | 0.001b | 0.003b | |
| NPI | 2.2 ± 5.1 | 2.9 ± 6.7 | 5.5 ± 8.3 | <0.001b, c | <0.001b, c | |
| Hippocampal_Volume, ml | 5809.7 ± 1018.6 | 5035.6 ± 1547.4 | 4727.5 ± 1226.7 | <0.001a, b | <0.001a, b | |
| Amyloid PET | ||||||
| Centiloid | 4.23 ± 9.93 | 1.90 ± 11.14 | 82.92 ± 35.08 | <0.001b, c | <0.001b, c | |
| CSF, pg/ml | ||||||
| Ptauf | 18.17 ± 6.28 | 20.75 ± 7.62 | 35.79 ± 17.66 | <0.001b, c | <0.001b, c | |
| Aβ42f | 1158.75 ± 844.23 | 1049.16 ± 1035.94 | 486.41 ± 416.34 | <0.001b, c | <0.001b, c | |
| Aβ42/Ptauf | 87.27 ± 24.80 | 79.40 ± 22.67 | 23.57 ± 16.42 | <0.001a, b, c | <0.001b, c | |
| Aβ42/Aβ40g | 0.08 ± 0.02 | 0.08 ± 0.02 | 0.03 ± 0.01 | <0.001b, c | <0.001b, c | |
| Ptau/Aβ40g | 0.0010 ± 0.0002 | 0.0011 ± 0.0003 | 0.0020 ± 0.0007 | <0.001b, c | <0.001b, c | |
p1, ANOVA, Kruskal-Wallis, or chi-square; p2, ANCOVA adjusted by age, sex, and diagnosis; p3, ANCOVA adjusted by age, sex, and education. Tukey posthoc analysis was conducted in p1 and Bonferroni posthoc analysis was conducted in p2 and p3.
Key: APOE, apolipoprotein E; Aβ, beta-amyloid; CI, cognitive impairment; CSF, cerebrospinal fluid; Ptau, hyperphosphorylated tau; GDS, geriatric depression scale; NL, normal cognition; MMSE, mini-mental state examination; NPI, neuropsychiatric inventory; PET, positron emission tomography; SUVR, standard uptake value ratio.
p < 0.05 between A-T- and A-T+
p < 0.05 between A-T- and A+T+
p < 0.05 between A-T+ and A+T+
Missing data 95
Missing data 372
Missing data 156
Missing data 287. Data are shown as mean ± SD or number (%).