Figure 3.

Anticoagulant venom activity of cobra venoms are inhibited by the PLA₂ inhibitor varespladib. H. haemachatus, N. haje, and N. naja additionally show significant inhibition by some marimastat doses. Clotting activity was measured as the mean area under the curve (AUC) of each sample type in the relevant clotting period (22–71 min), standardised by the mean AUC of the negative control in the same period. Error bars represent the standard error of the mean (SEM) of 3–4 measurements (some sample wells needed to be removed due to disruption in readings caused by bubbles). Asterisks represent significant increases in coagulant activity as measured by one-way ANOVA and Dunnett’s Multiple Comparison post-hoc testing; *—p < 0.05, **—p < 0.01, ***—p < 0.0001.