Table 4.
Lymphotoxin alpha (LTA) and superoxide dismutase 1 (SOD1) and 2 (SOD2) genetic polymorphisms and corresponding genotype frequencies in 172 migraine patients with (n = 38) or without (n = 134) white matter hyperintensities (WMHs).
| Genotype Frequencies * | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Allele Frequencies | Without WMHs | With WMHs | ||||||||||||
| Rs | SNP | Without WMHs | With WMHs | WT | HET | HOM | WT | HET | HOM | OR (C.I.) | AIC | p | ||
| LTA | ||||||||||||||
| rs2071590 | C→T | 0.61 | 0.39 | 0.55 | 0.45 | 0.37 | 0.49 | 0.14 | 0.21 | 0.68 | 0.11 | 2.23 (1.04–4.79) | 181 | 0.034 † |
| rs2844482 | A→G | 0.12 | 0.88 | 0.14 | 0.86 | 0.02 | 0.20 | 0.78 | 0.00 | 0.29 | 0.71 | 1.69 (0.74–3.85) | 184 | 0.22 |
| SOD1 | ||||||||||||||
| rs2234694 | A→C | 0.97 | 0.03 | 0.87 | 0.13 | 0.94 | 0.06 | 0.00 | 0.76 | 0.21 | 0.03 | 4.89 (1.74–13.8) | 177 | 0.003 ‡ |
| SOD2 | ||||||||||||||
| rs4880 | C→T | 0.51 | 0.49 | 0.45 | 0.55 | 0.27 | 0.43 | 0.30 | 0.21 | 0.47 | 0.32 | 0.92 (0.42–2.01) | 185 | 0.84 |
* Eleven patients with cerebrovascular lesions were excluded from the analysis. † p value for SNP association with WMHs in an over-dominant model. ‡ p value for SNP association with WMHs in a dominant model. SNP, single nucleotide polymorphism; WT, wild type; HET, heterozygous; HOM, homozygous; AIC: Akaike information criterion.