Figure 3.

Schematic representation of interactions between platelets, leukocytes (e.g., neutrophils), and endothelial cells in thrombo-inflammation. Platelets interact with both endothelial cells and leukocytes through a variety of receptors/adhesion molecules. Besides activation of platelets, the interactions may induce endothelial cell responses, including apoptosis and inflammation. The interactions between platelets and leukocytes might result in prothrombotic platelet/leukocyte aggregates as well as activation of coagulation through released components of neutrophils. Created with Biorender.com accessed on 10 October 2022.