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. 2022 Nov 25;10(12):e748. doi: 10.1002/iid3.748

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© 2022 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Anti‐P1, anti‐P2, and anti‐N IgG antibody levels (A) and IgG2a antibody levels (B) in mice sera immunized with combined vaccine formulations with Alhydrogel (K2) or Alhydrogel + MPLA (K3) as the adjuvant, respectively. (C) Antigen‐specific IFN‐γ levels as determined in splenocytes of mice immunized with K2 or K3. One‐way ANOVA followed by Dunnett's multiple comparisons test was used for statistical analysis. *p < .05, **p < .01, ***p < .001, ****p < .0001. ANOVA, analysis of variance; ConA, concanavalin A; IFN‐γ, interferon‐γ; MPLA, monophosphoryl lipid A.