FIGURE 2.

Change in body weight during drug treatments and survival. All animals except naïve controls received bleomycin treatment from day 1–28 and test agents beginning 24 h before the first bleomycin treatment until day 42 (A) Stress on the animals was observed in the rapid weight loss during the first week in the nintedanib and prednisolone groups, and a lack of significant weight gain over the 6 weeks study in all groups except 100 mg/kg CCG‐257081. (B) Survival curves highlight the increased mortality rate in the group receiving prednisolone. Due to excessive weight loss and animal loss, the dose of prednisolone was lowered from 15 to 5 mg/kg. In all other groups, loss of animals is believed due to complications with the daily oral gavage of drug. Weight change time courses, which are significantly different from the vehicle control, are marked (*p < .05, **p < .01). Groups: naïve control (n = 6), bleomycin + vehicle (n = 10), 10 mg/kg CCG‐257081 (n = 15), 30 mg/kg CCG‐257081 (n = 15), 100 mg/kg CCG‐257081 (n = 10), 30 mg/kg nintedanib (n = 10), and prednisolone (15 mg/kg Days 1–7, 5 mg/kg Days 8–42, n = 10)