Table 4.

Chemical exposure impacts on Hippo pathway core components

Study (first author, year)	Model system	Chemical exposure	Findings
Zhang et al., 2018	Primary mouse granulosa cells	Zearalenone (30μM)	Altered granulosa cell morphology; increased transcripts of Yap1, Taz, Tead3; increased protein expression YAP1, TAZ
	Mouse model—in vivo	Zearalenone (40-100 μg/kg)	Increased transcripts of Yap1, Taz; decrease in follicle number
Hu et al., 2019	Mouse model—in vivo	Tri-ortho-cresyl phosphate (TOCP)	Increased protein expression MST1, LATS2, decrease YAP1 protein; decline in follicle number; increase in atretic follicles; protective effect of YAP1 OE
Clark et al., 2022	HGrC1 cell line	Perfluorooctanoic acid (PFOA)	Increased cell proliferation and migration; elevated YAP1 and CTGF protein expression

Abbreviations: CTGF, connective tissue growth factor; LATS2, large tumor suppressor 2; MST1, mammalian serine/threonine-protein kinase 4; OE, overexpression; TAZ, WW domain-containing transcription regulator 1 (also known as WWTR1); TEAD, TEA domain transcription factor; YAP1, yes-associated protein 1.