Table 6.
Knockout/overexpression studies of Hippo pathway core components and ovarian cancer phenotypes
| Study (first author, year) | Model system | Gene targeted | Overexpression/knockout | Findings |
|---|---|---|---|---|
| St John et al., 1999 | Lats1 -/- mouse model | LATS1 | KO | Development of ovarian stromal tumors |
| Xia et al., 2014 | A2780 cell line | YAP1 | OE | Increased cancer cell proliferation and migration; enhanced anchorage-independent growth; increased chemoresistance |
| KO | Decreased cancer cell proliferation and migration; increased chemosensitivity | |||
| OVCAR8 cell line | YAP1 | OE | Increased cancer cell proliferation and migration; enhanced anchorage-independent growth; chemoresistance | |
| KO | Decreased cancer cell proliferation and migration; increased chemosensitivity | |||
| He et al., 2015 | HOSE-T80 cell line | YAP1 | OE | Increased cancer cell proliferation; malignant transformation; enhanced anchorage-independent growth; induced tumorigenesis in vivo |
| KO | Suppressed cancer cell proliferation | |||
| TOV21G cell line | YAP1 | OE | Increased cancer cell proliferation; malignant transformation; enhanced anchorage-independent growth; induced tumorigenesis in vivo | |
| KO | Suppressed cancer cell proliferation | |||
| Hua et al., 2016 | FTSEC cell lines | YAP1 | OE | Increased cancer cell proliferation; malignant transformation; enhanced anchorage-independent growth; induced tumorigenesis in vivo |
| KO | Suppressed cancer cell proliferation | |||
| Lv et al., 2020 | HGrC1 cell line | YAP1 | OE | Induced tumorigenesis in vivo |
| HGL5 cell line | YAP1 | OE | Induced tumorigenesis in vivo |
Abbreviations: KO, knockout; LATS1, large tumor suppressor 1; OE, overexpression; YAP1, yes-associated protein 1.