Table 3.

Simple regression (Pearson correlation coefficient) and multiple regression using the orthogonal projections to latent structures (OPLS) model of independent variables on the quantitative insulin sensitivity check index (QUICKI) in males and females.

	Pearson Correlation				OPLS (VIP)
	Males (n = 162)	p	Females (n = 147)	p	Males	Females
CMSS4	−0.308	<0.001	−0.359	<0.001	1.44	1.39
Fructosamine	−0.259	0.001	−0.070	0.401	1.22	0.29
Total body fat	−0.179	<0.001	−0.255	0.002	1.15	1.09
Non-HDL-C	−0.204	0.009	−0.154	0.062	1.12	0.85
Log C-reactive protein	−0.187	0.024	−0.198	0.016	0.69	0.94
Uric acid	−0.075	0.345	−0.120	0.147	NI	NI
EGFR	−0.032	0.690	−0.010	0.224	NI	NI
Log ACR	0.162	0.059	−0.078	0.383	NI	NI
Log TBARS	0.095	0.233	−0.163	0.051	0.77	0.76
Log methylglyoxal	−0.015	0.849	−0.208	0.011	0.90	0.98
Glyoxal	0.026	0.741	−0.198	0.016	0.92	1.08
3-DG	−0.553	<0.001	−0.546	<0.001	1.86	1.99
Log free MG-H1	−0.165	0.036	−0.310	<0.001	0.73	1.18
Log free CML	0.115	0.144	−0.064	0.443	0.73	0.96
Free CEL	−0.110	0.163	−0.165	0.045	0.71	1.11
Log pb-pentosidine	−0.066	0.403	0.059	0.479	0.57	0.19
Pb-MGH1	0.354	<0.001	0.012	0.884	1.50	0.13
Log pb-CML	0.167	0.033	0.111	0.181	0.90	0.58
Log pb-CEL	0.115	0.144	−0.348	<0.001	0.87	1.20
SRAGE,	−0.146	0.064	0.165	0.046	NI	NI
EsRAGE	−0.015	0.853	0.067	0.418	NI	NI
CRAGE,	−0.182	0.021	0.179	0.030	1.04	0.77
Log cRAGE/esRAGE	−0.153	0.051	0.123	0.137	NI	NI
Log sVAP-1	−0.140	0.075	−0.073	0.378	0.76	0.39
Log u-MGH1	−0.104	0.191	−0.218	0.012	0.73	1.23
Log u-CML	−0.092	0.248	−0.122	0.166	0.58	0.97
Log u-CEL	−0.090	0.257	−0.196	0.025	0.66	0.99
Log FEMGH-1	0.180	0.176	0.040	0.651	NI	NI
Log FECML	−0.204	0.010	−0.082	0.353	NI	NI
Log FECEL	0.049	0.536	−0.063	0.472	NI	NI
	n = 110		n = 92
Log u-D-lactate	0.090	0.349	−0.192	0.066	NI	NI
R2	-	-	-	-	0.46	0.48

cMSS4 continuous metabolic syndrome score without glycemia, HDL-C high-density lipoprotein cholesterol, NI not included, eGFR estimated glomerular filtration rate, ACR urinary albumin-to-creatinine ratio, TBARS thiobarbituric acid reactive substances, 3-DG 3-deoxyglucosone, MG-H1 methylglyoxal-derived hydroimidazolone, CML N^ε-(carboxymethyl)lysine, CEL N^ε-(carboxyethyl)lysine, pb protein bound, sRAGE soluble receptor for advanced glycation end-products, esRAGE endogenous secretory receptor for advanced glycation end-products, cRAGE cleaved soluble receptor for advanced glycation end-products, sVAP-1 soluble vascular adhesion protein-1, u urinary, FE fractional excretion, significant p for simple correlations and variable importance for the projection values (VIP > 1.0) considered as significant predictors in the OPLS regression models are given in bold.