Table 3.
The molecular descriptor and parameters of Lipinski’s, Ghose’s, and Veber’s rules for palmatine (1), metformin (2) & glimepiride (3) data here.
No | Molecular Mass (M) | H-Bond Acceptors | H-Bond Donors | Rotatable Bonds | TPSA | LogP Consensus |
Lipinski’s Rules |
Ghose’s Rules |
Veber’s Rules |
Muegge’s Rules |
---|---|---|---|---|---|---|---|---|---|---|
1 | 352 | 4 | 0 | 4 | 40.80 | 2.64 | + | + | + | + |
2 | 129 | 3 | 2 | 4 | 36.93 | 0.75 | + | - | + | - |
3 | 490 | 11 | 5 | 3 | 133 | 2.76 | + | - | - | + |