Table 1.
The composition and characterization parameters of different SLNs formulations.
| Formulation Code | Lipid Type | Lipid to QCT Ratio | Stabilizer Type | Stabilizer Concentration (%w/v) |
PS (nm) | PDI | ZP (mV) | EE (%) | DL (%) |
|---|---|---|---|---|---|---|---|---|---|
| Pr-QCT-SLNs-1 | Precirol | 15:1 | Tween 80 | 1.25 | 182 ± 3 | 0.33 ± 0.01 | - | 65 ± 1.2 | - |
| Pr-QCT-SLNs-2 | Precirol | 15:1 | Tween 80 | 2.5 | 131 ± 2 | 0.27 ± 0.02 | - | 60.3 ± 1 | - |
| Pr-QCT-SLNs-3 | Precirol | 15:1 | Tween 80 | 5 | 114 ± 2 | 0.22 ± 0.01 | - | 45.6 ± 1.5 | - |
| Pr-QCT-SLNs-4 | Precirol | 30:1 | P188 | 0.1 | 691 ± 14 | 0.38 ± 0.07 | - | 98.2 ± 0.6 | - |
| Pr-QCT-SLNs-5 | Precirol | 30:1 | P188 | 0.5 | 341 ± 3 | 0.18 ± 0.01 | - | 98.4 ± 0.6 | - |
| Pr-QCT-SLNs-6 | Precirol | 30:1 | P188 | 0.75 | 364 ± 9 | 0.25 ± 0.01 | - | 98.8 ± 0.8 | - |
| Pr-QCT-SLNs-7 | Precirol | 5:1 | P188 | 0.5 | 346 ± 21 | 0.46 ± 0.04 | - | 98.6 ± 1 | 19.2 ± 1 |
| Pr-QCT-SLNs-8 | Precirol | 10:1 | P188 | 0.5 | 220 ± 2 | 0.32 ± 0.02 | −33 ± 7 | 99 ± 1.1 | 8 ± 0.5 |
| Pr-QCT-SLNs-9 | Precirol | 15:1 | P188 | 0.5 | 304 ± 1 | 0.33 ± 0.02 | - | 98.4 ± 0.7 | 5.5 ± 0.4 |
| Pr-SLNs-8 | Precirol | 10:1 | P188 | 0.5 | 264 ± 4 | 0.25 ± 0.02 | - | - | - |
| C-Pr-QCT-SLNs-8 | Precirol | 10:1 | P188 | 0.5 | 243 ± 3 | 0.33 ± 0.03 | 20 ± 4 | 98.4 ± 1 | 6.7 ± 0.4 |
| St-QCT-SLNs-1 | Stearic acid | 5:1 | P188 | 0.5 | 323 ± 7 | 0.32 ± 0.03 | - | 98 ± 0.7 | 18.1 ± 1.1 |
| St-QCT-SLNs-2 | Stearic acid | 10:1 | P188 | 0.5 | 262 ± 7 | 0.23 ± 0.01 | −34 ± 7 | 98.3 ± 1.5 | 8.87 ± 0.3 |
| St-QCT-SLNs-3 | Stearic acid | 15:1 | P188 | 0.5 | 359 ± 7 | 0.19 ± 0.02 | −37 ± 7 | 98 ± 1 | 6.27 ± 0.1 |
| St-SLNs-2 | Stearic acid | 10:1 | P188 | 0.5 | 240 ± 5 | 0.13 ± 0.03 | - | - | - |
| C-St-QCT-SLNs-2 | Stearic acid | 10:1 | P188 | 0.5 | 275 ± 3 | 0.21 ± 0.02 | 29 ± 6 | 99 ± 1.2 | 8.85 ± 0.6 |
Results are presented as mean ± standard deviation (n = 3). Abbreviations: PS: particle size, PDI: polydispersity index, ZP: zeta potential, EE: entrapment efficiency, DL: drug loading, P188: poloxamer 188, QCT: quercetin, Pr: precirol, St: stearic acid, C: coated, SLNs: solid lipid nanoparticles.