Table 6.
The association of E-cadherin expression with histopathological type of EOC patients.
| Number of All Patients | Histopathological Type | Number of Preserved/Positive Patients (%) | Number of Reduced/Negative Patients (%) | p Value | Localization | Cutoff [%] | Ref. | |
|---|---|---|---|---|---|---|---|---|
| 73 | Serous mucinous endometrioid clear cell |
9 (31) 9 (69) 11 (79) 7 (64) |
20 (69) * 4 (31) 3 (21) 4 (36) |
* 0.023 | M + C | Nd | [26] | |
| 76 | Serous mucinous endometrioid clear cell |
5 (16) 6 (46) 7 (50) 6 (54.5) |
27 (84) * 7 (54) 7 (50) 5 (45.5) |
* 0.028 | M | Nd | [26] | |
| 74 | Serous mucinous endometrioid clear cell |
1 (3) 2 (15) 1 (7) 2 (18) |
29 (97) 11 (85) 13 (93) 9 (82) |
0.311 | C | Nd | [26] | |
| 123 | Serous mucinous endometrioid clear cell |
Nd | 28 (44) 16 (67) 6 (58) 13 (52) |
0.320 | M | 10 | [43] | |
| 282 | Serous mucinous endometrioid clear cell |
22 (22) 20 (67) 17 (23) 11 (37) |
80 (78) * 10 (33) 57 (77) ** 19 (63) |
* <0.0005 ** <0.0005 |
M | 5 | [49] | |
| 300 | Serous mucinous endometrioid clear cell |
52 (31) 19 (30) 16 (30) 4 (27) |
116 (69) 44 (70) 38 (70) 11 (73) |
0.982 | NL | 5 | [54] | |
| 77 |
Serous mucinous endometrioid clear cell |
Weak 8 0 5 5 |
Strong 17 (63) 7 (100) 12 (71) 21 (81) |
Nd | ns | NL | 1 | [55] |
| 68 |
Serous mucinous endometrioid clear cell |
Low 9 (39) 3 (43) 8 (47) 12 (57) |
High 6 (26) 3 (43) $ 7 (41) 4 (19) |
8 (34) 1 (14) 2 (12) 5 (24) |
$ <0.001 | NL | Nd | [56] |
| 64 | Serous mucinous endometrioid clear cell |
Nd | 10 (36) 2 (20) 1 (17) 2 (50) |
0.71 | M | 25 | [57] | |
| 46 | Serous mucinous endometrioid |
7 (41) 5 (83) 6 (60) |
10 (59) 1 (17) 4 (40) |
0.36 | NL | 10 | [58] | |
| 73 |
Serous mucinous endometrioid |
IRS 5.29 ± 0.52 4.62 ± 1.00 5.03 ± 0.53 |
Nd | ns | NL | 1 | [68] | |
| 84 | Serous mucinous endometrioid clear cell |
1 (4) 8 (61.5) # 1 (8) 5 (16) |
27 (96) * 5 (38.5) 11 (92) 26 (84) |
* <0.001 # <0.001 |
NL | 10 | [69] | |
| 104 | Serous mucinous endometrioid clear cell |
10 (27) 15 (40) 3 (8) 8 (22) |
46 (69) * 7 (10) 5 (8) 8 (12) |
* 0.001 | M | 1 | [70] | |
Nd—no data; ns—not significant; NL—not localized; M—membranous; C—cytoplasmic; M + C—membranous + cytoplasmic (total). * Reduced expression of E-cadherin significant in serous HP; ** reduced expression of E-cadherin significant in endometrioid HP; # positive expression of E-cadherin significant in mucinous HP; $ high positive expression of E-cadherin significant in mucinous HP.