. 2022 Oct 30;10(11):2152. doi: 10.3390/microorganisms10112152

Table 4.

Antifungal drugs used for the treatment of sporotrichosis.

Antifungal	Administration Route	Patients	Dosage	Indications	Reference
Potassium iodide (KI)	oral	Humans (children/elderly)	15 mg/kg/day	Humans in the endemic area	[74], [76], [81,82], [87], [89,90], [96]
Potassium iodide (KI)	oral	cats	2.5–20 mg/kg/day plus ITZ cat dosage	Cats presenting multiple skin and mucosal lesions, or presence of respiratory signs; Cases refractory to ITZ monotherapy	[74], [76], [81,82], [87], [89,90], [96]
Itraconazole (ITZ)	oral	Humans (adults)	100 to 400 mg/day	Healthy patients with limited lesions, immunosuppressed patients and in the systemic form	[74], [77,78,79], [82], [87], [90,91,92,93], [96], [105,106,107,108,109,110,111,112,113,114,115,116,117,118]
Itraconazole (ITZ)	oral	cats	25 mg–100 mg/kg/day	Cats with fixed cutaneous lesions and naïve to antifungal therapy
Terbinafine (TRB)	Oral	Humans (adults)	250–500 mg/day	Cutaneous sporotrichosis; cases which itraconazole was contraindicated	[87], [91], [99], [107], [115], [118]
Terbinafine (TRB)	Oral	cats	30 mg/kg/day		[87], [91], [99], [107], [115], [118]
Amphotericin B (AMB)	Deoxycholate (intravenous)	Humans (adults)	0.3–1 mg/kg/day	Disseminated forms sporotrichosis	[80], [84], [86], [87], [91], [93], [96], [107], [117,118]
Amphotericin B (AMB)	Liposomal (intravenous)	Humans (adults) and cats (rarely)	3–5 mg/kg/day	Disseminated forms sporotrichosis	[80], [84], [86], [87], [91], [93], [96], [107], [117,118]