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. 2022 Nov 4;12(11):1786. doi: 10.3390/life12111786

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Coronal section of brain-tumor-model rat after 120 min administration. (b) BPA biodistribution image generated by MALDI-MSI. BPA penetration is mainly observed in brain tumor tissue. No BPA is visible in the lateral ventricle. BPA is localized in the invasive margin (➤) of the brain tumor and clearly distinguishes the border between tumor and normal cells. Our results imply that BPA penetrated the brain tumor cells within 120 min following administration via blood circulation of the brain-tumor-model rat.