Table 1.

The potential opportunities from in silico studies and Pk/PD models.

STANDARD MODELS
Pk Models for Anesthesia Administration	Application
Marsh et al. [64]	Propofol target-controlled infusion (TCI) syringe pumps
Schnider et al. [65]
Eleveld et al. [66]	Predicting propofol concentrations and the bispectral index
Necessary studies to model Pk/PD of anaesthetics drugs for cancer patients
Objective of the study:
1. Assess ADMET properties of all anesthetic drugs used in cancer patients (e.g., Gaussian accelerated molecular dynamics) to further understand the interactions between propofol and fentanyl;
2. Assess the interaction of anesthetics drugs with the chemotherapeutics;
3. Model tumor growth and assess the involvement of drug anesthesia in its progression and metastasis (e.g., multiparametric imaging data).