Figure 2.

Graphics from Avogadro to illustrate the tedious and error-prone nature of converting generic 3D RNA aptamer structures into their DNA counterparts. The process includes deleting all 2′ hydroxyl groups on ribose rings at the 2′ oxygen atoms (top panel) and addition of methyl groups to all uracil rings (red arrow at lower left panel) as shown to convert them to thymines (red circled methyl group on thymine lower right panel).