Figure 3.

(A–D) A truncated aptamer loop designated B13 was developed against 13-HODE, but clearly also swallows the 9-HODE isomer and linoleic acid precursor as well when docked using PatchDock and visualized with YASARA to account for its dominant heat and burn pain analgesia in a rat model (i.e., the truncated B13 aptamer loop is capable of binding and blocking linoleic acid and both of its oxidized pain-inducing products). YASARA stands for “Yet Another Scientific Artificial Reality Application” 3D molecular modeling software.