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. 2022 Nov 2;14(11):2434. doi: 10.3390/v14112434

Figure 2.

Figure 2

Schematic diagram of the PEDV genome structure. Non-structural proteins, including nsp1–nsp16; structural proteins, including spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins; accessory proteins, ORF3. The spike protein consists of two subdomains, S1 and S2. The S1 subunit can be further subdivided into 6 domains, including signal peptide (SP, 1–18 aa, brown), domains 0 (19–219 aa, purple), domains A (220–509 aa, blue), domains B (510–639 aa, green), domains C and D (640–728 aa, yellow). The S1 subunit contains two receptor binding domains (RBDs): the N-terminal domain (S1-NTD, 19–252 aa) and the C-terminal domain (S1-CTD, 509–638 aa). The S2 subunit contains 3 domains, including two heptapeptide repeat domains (HR1 and HR2, 978–1117 aa and 1274–1313 aa) and a transmembrane domain (TM, 1324–1346 aa).