Table 3.
Amino acid changes on the S protein of PEDV attenuated strains.
| ORFs | PC22A-P120 [139] | CT-P120 [140] | PT-P96 [141] | YN144 [47] | FJzz1-F200 [110] | OH851 [51,64] | |
|---|---|---|---|---|---|---|---|
| S1 | domains 0 | 55–57IGE→K–, I166V | T144I | ∆144–145TG | 55–57IGE→K–, F128Y | S88A, N130D, N132K | |
| domains A | Q454K, D466G, ^477H | D265A | D405G, G428A | D265A, D378N, T491R | T361A | ||
| domains B/COE | F636R | F555S | |||||
| domains CD | S723R | A694D | |||||
| S2 | V881F, Q893K, A971V, G1009V, F1015L, E1379 stop | S888R, C1363G | S888R, S969A, I1022S, K1027R, L1253R, C1355F, C1359F | T780N, Q826H, I1011V, I1305L, C1355F | K774N, 888–889SG →RR, L901V, N1010D, I1340T, C1355F | G1162S, V1242L | |
1. The amino acid changes of the attenuated strains CT-P120, PT-P96, YN144, FJzz1-F200, PC22A-P120, and OH851 are based on the nucleotide sequences of CT-P10, PT-P5, YN15, PC22A-P3, FJzz1-F20, and GER/L00719/2014, respectively. 2. The residue positions on each domain were referenced to the S protein of the PC22A strain (GenBank: KM392224.1). 3. S1 subunit domains 0, residues 19 to 219; domains A, residues 220 to 509; domains B/COE, residues 510 to 639; domains CD, residues 640 to 728; S2 subunit, residues 729 to 1387 [142]. 4. ^477H, aa H was inserted at residue 477.