Strategies that enhance the therapeutic effect of MTPTT through inhibiting energy or metabolism. (A) Illustration of GOx-induced starvation for enhanced MTPTT in a hypoxic TME via the PHPBNs-mediated tumor reoxygenation [29]. Copyright © 2022, American Chemical Society. (B) Schematic illustration of thermosensitive liposomes encapsulating GOx, ICG, and GA for synergistic starvation therapy, EEPT, and enhanced MTPTT of tumors [91]. Copyright © 2022 John Wiley and Sons. (C) Schematic illustration of GNR/HA-DC for selectively sensitizing tumor cells to MTPTT by interfering with the anaerobic glycolysis metabolism [92]. Copyright © 2022, American Chemical Society.