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. 2022 Oct 24;14(11):2279. doi: 10.3390/pharmaceutics14112279

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MTPTT assists in distinct types of immunotherapies. (A) The schematic of the disassembly process of PCN and an immunofavorable TME was established via a fever-like immune response induced by the photothermal effect of PCN [150]. Copyright © 2022, The Author(s). (B) Schematic structure of GO-FA-SNX-2112 and its application for MTPTT of the tumor to induce overactivation of autophagy; stimulated autophagy not only causes tumor cells to die directly but also makes them be captured by immunity because of the decrease in PDL1 receptor expression; residual surviving tumor cells are also gradually killed by restored immune cells, to achieve efficient inhibition of tumor growth [32]. Copyright © 2022, American Chemical Society. (C) Schematic illustration of the symbiotic mild photothermal-assisted immunotherapy via a combined all-in-one and all-in-control strategy [159]. Copyright © 2022, The Author(s).