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. 2022 Nov 13;23(22):14014. doi: 10.3390/ijms232214014

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CISD2 attenuates heart and skeletal muscle aging. (A) An age-dependent decrease in CISD2 correlates with cardiac dysfunctions and molecular pathological alterations. Whole-body CISD2 overexpression (CISD2 TG) delays age-associated cardiac damage. In addition, the CISD2 activator, hesperetin (Hes), reverses age-associated cardiac damage via the activation of CISD2. (B) Age-dependent CISD2 reduction leads to sarcopenia and pathological alterations. Maintaining a high level of CISD2 by transgenic overexpression, or by hesperetin treatment, is able to protect skeletal muscle from age-related pathological and molecular damage. The figure was created with BioRender.com.