Table 1.

Regimens or treatments that enhance CISD2 gene expression.

Compound or Intervention	Treatment and Duration	Tissue or Cell Line	Animal Model or Human Subjects	Enhance CISD2 Expression	Reference
A. In Vitro Cell Study
Hesperetin	10 and 30 μM for 24 h	HEK293-CISD2 reporter cells		CISD2 reporter	[75]
Hesperetin -7-O-sulfate	30 μM for 24 h	HEK293-CISD2 reporter cells		CISD2 reporter	[75]
Curcumin	1 μM for 24 h	SH-SY5Y Rat primary astrocyte		CISD2 mRNA	[38]
Wild bitter melon extract	1 μg/mL for 24 h	Astrocyte cell line	LPS-challenged ACL	CISD2 mRNA	[73]
α-Eleostearic acid	0.28 μg/mL for 24 h	Astrocyte cell line	LPS-challenged ACL	CISD2 mRNA	[73]
Sophoricoside	10 and 30 μM for 24 h	HEK293-CISD2 reporter cells		CISD2 reporter	[75]
Genistein	10 and 30 μM for 24 h	HEK293-CISD2 reporter cells		CISD2 reporter	[75]
Formononetin	10 and 30 μM for 24 h	HEK293-CISD2 reporter cells		CISD2 reporter	[75]
B. Animal Study
Exercise
	Treadmill exercise for 8 weeks	Whole body (ventral view)	CISD2 reporter mice	CISD2 reporter	[66]
	Exercise with a running wheel for 4 weeks	Skeletal muscle eWAT	Male C57BL/6J mice	CISD2 protein	[67]
Hesperetin
	100 mg/kg/day (provided in food) for 5 months	Heart Skeletal muscle	Aged mice (26 months old)	CISD2 protein	[75]
	100 mg/kg/day (provided in food) for 6 weeks	Whole body (ventral view)	CISD2 reporter mice	CISD2 reporter	[75]
Curcumin
	40 mg/kg/day (i.p. injection) for 2 days	Spinal cord	Aged mice (24 months old)	CISD2 protein	[38]
	40 mg/kg/day (i.p. injection) for 2 days	Spinal cord	Spinal cord hemisectionin mice	CISD2 mRNA	[71]
Miscellaneous
Wild bitter melon extract	500 mg/kg (i.p. injection) for single dose	Spinal cord	Spinal cord hemisection in mice	CISD2 mRNA and protein	[73]
ESM powder	Diet with 10 g/kg ESM powder for 14 days	Liver	Wistar rats	CISD2 mRNA	[74]
HEM powder	Diet with 10 g/kg HEM powder for 14 days	Liver	Wistar rats	CISD2 mRNA	[74]
C. Human Study
RYGB surgery	3 months post-RYGB	Skeletal muscle	Obese females (BMI > 40 kg/m2)	CISD2 protein	[59]