Table 2.
DEGs influenced by hesperetin through CISD2-dependent or CISD2-independent pathways.
| CISD2 Dependent | CISD2 Independent | |
|---|---|---|
| A. Lipid Metabolism | ||
| Lipogenesis | Srebp1 | |
| Fatty acid oxidation | Slc22a5, Fabp3, Cpt1, and Ucp3 | |
| Malonyl CoA metabolism | Mlycd | |
| Pyruvate metabolism | Pdk4 | |
| Phospholipid synthesis | Agpat1 | Agpat3 and Pla2g12a |
| Others | Abcd3, Scd2, Pdss2, Cot7, Insig1, Synj2, Nceh1, and Pigq | |
| B. Proteostasis | ||
| Ubiquitin proteasome system |
Zyg11b, Tspan15, Hspbp1 | |
| Autophagy-lysosome system |
Rb1cc1, Cct2, Rab4a, Scarb2, and Lamtor3 | |
| Others | Serp1, Paip1, Gspt1, Rpl34, Eif3g, Lrpprc, Mrps9, Cct4, Sugt1, Cox17, Cd24a, Rap1gds1, Kank1, Spag9, Pdss2, Nceh1, Fiz1, Adck1, Cript, and Ccdc47 | |
| C. Nitrogen, Protein & Amino Acid Metabolism | ||
| Methionine | Mat2b | |
| Glutamate | Slc25a22 | |
| Proline | Pycrl | |
| Protein transport | Timm17b | |
| Others | Irf2, Smndc1, Zhx2, Cct4, Srebf1, Csde1, Mrps9, Tbx15, Ddx1, Pura, Acot7, Rap1gds1, Rb1cc1, Fiz1, Gspt1, Gm20390, Cct2, Hnrpll, Hist2h2aa1, and Lrpprc | Cops2, Hfe2, Taf9b, Slu7, and Tmem14c |
| D. Miscellaneous (Aging and Mitochondrial Function) | ||
| Aging | Serp1 and Coq7 | |
| Mitochondrial function | Cox17, Slc22a5, Immt, Cd24a, Synj2, Coq7, Lrpprc, Cox4i1, and Ndufb9 | |
| Immune response and inflammation | Ddx1, Pdk4, Fgfbp1, Slc22a5, Sugt1, and Cd24a | |