Table 1.
Activity of the studied compounds against intracellular forms of T. cruzi (Tulahuen strain), toxicity on L929 cells and selective indexes (SI) after seven days of compound incubation.
| Compound | Activity on Intracellular Forms | Toxicity on L929 IC50, µM |
SI * | |
|---|---|---|---|---|
| (EC50, µM) | (EC90, µM) | |||
| Bz | 1.97 (1.36 to 2.86) | 5.54 (2.66 to 8.42) | >200 | >101.5 |
| FH11706 (1) | 1.11 (0.62 to 1.97) | >30 | 118.5 (75.31 to 186.4) | 106.7 |
| FH10714 (2) | 0.47 (0.24 to 0.93) | 6.19 (0.58 to 12.96) | 55.75 (48.37 to 64.25) | 118.6 |
| FH8513 (3) | 0.20 (0.10 to 0.41) | 1.61 (0.32 to 2.90) | 22.27 (13.63 to 36.38) | 111.3 |
* SI represent the ratio of IC50 and EC50 values (IC50/EC50). Data represent the average of three independent determinations; 95% of confidence intervals are indicated.