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Cardiotoxic profile (IC50) of the studied compounds using 2D and 3D cultures of H9C2 after seven days of compound incubation.
| Compounds | IC50 (µM) | |
|---|---|---|
| 2D | 3D | |
| Bz | >200 | >200 |
| Pt | 45.98 (15.39 to 137.4) | >200 |
| FH11706 (1) | 47.71 (32.62 to 69.79) | >200 |
| FH10714 (2) | 41.82 (25.23 to 69.30) | 180.8 (153.6 to 208) |
| FH8513 (3) | 18.57 (11.36 to 30.36) | 199.8 (120.4 to 331.4) |
Values are the average of three independent determinations; 95% of confidence intervals are indicated.
